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Topics on Cell Cycle and Differentiation

Code: 
BIOL-408
Semester: 
Winter Semester
Course type: 
Selection
Course units: 
3
ECTS units: 
4

Hours per week

Theory: 
2

Instructors

Description

Objectives of the course (preferably expressed in terms of learning outcomes and competences):  Learning the basic principles of cell cycle progression and the molecular components controlling the eukaryotic cell cycle (mechanisms for activation, inhibition and ckeckpoint mechanisms).

Course contents:   Cell cycle controlling mechanisms. Introduction, cell cycle phases, MPF, cyclins (early embryos, animal cells). Yeasts as model systems to study cell cycle, cdc mutations. Regulatory factors for entrance, progression and exit through mitosis, G1 and S phases in S. pombe and S. cerevisiae. How regulated proteolysis leads the cell cycle. Multiple controls of cell cycle phases (genetic and biochemical analysis). Cell division control in multicellular organisms. Kinase-cyclin dimers (Cdks), Cdk inhibitors (Ckis), growth factors, tumor  suppressors Rb and p53. Cell culture characteristics. S phase (DNA replication) controlling mechanisms. Checkpoints in the cell cycle of yeasts and mammals (mitosis, DNA damage). Alternative topic: Differentiation pathways in S. cerevisiae

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The Department of Biology of the University of Crete was established in 1981 and is today an internationally recognized center for contemporary university education and research in the field of Biology.

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