Hours per week
Objectives of the course (preferably expressed in terms of learning outcomes and competences): To understand the basic mechanisms which shape evolution of molecules.
Course contents: Dynamics of mutations. Advantageous, deleterious and neutral mutations. Estimating the number of nucleotide substitutions between sequences. Rates and patterns of nucleotide substitutions. Increase of genetic information in genomes. Evolution by gene duplication and domain shuffling. Evolution by transposition and horizontal gene transfer. Concerted evolution of multigene families. Evolution of coding and non-coding genomic sequences. DNA polymorphism in populations. Molecular clocks. Molecular phylogenetics.