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When Biochemistry meets Epigenetics

Code: 
BIOL-414
Semester: 
Winter Semester
Course type: 
Selection
Course units: 
3
ECTS units: 
4

Hours per week

Theory: 
3

Instructors

Associate Professor

Description

Course contents:

  • An introduction to Epigenetics
  • Biochemical mechanisms of Epigenetics DNA methylation, recognition of methylated CpG, demethylation in mammals, histone modifications, non-coding RNAs, microRNAs, the effect of chromosome organization, mechanisms of polycomb proteins
  • Biochemical approaches to study Epigenetics Analysis of tissue-specific DNA methylation, methods for assessing genome-wide DNA methylation, methylation of Lysine-9 of Histone H3: role in heterochromatin modulation and tumorigenesis, chromatin modifications distinguish genomic features and physical organization of the nucleus, assessing epigenetic information
  • Model Organisms of Epigenetics Eukaryotic microbes, Drosophila, mouse models of epigenetic inheritance, epigenetic regulatory mechanisms in plants
  • Metabolism and Epigenetics
  • Functions of Epigenetics Stem Cells and cellular differentiation, Epigenetic basis of skeletal muscle regeneration, X Chromosome Inactivation, genomic imprinting, Epigenetics of memory processes, transgenerational Epigenetics, aging Epigenetics
  • Evolutionary Epigenetics Epigenetics in adaptive evolution and development
  • Epigenetic Epidemiology The Effects of diet on Epigenetic processes, environmental agents and Epigenetics, impact of microbial infections on the human Epigenome and carcinogenesis, population pharmacoepigenomics
  • Epigenetics and Human Disease Cancer Epigenetics, the role of Epigenetics in Immune disorders, Epigenetics of brain disorders, complex metabolic syndromes and Epigenetics, clinical applications of Histone Deacetylase Inhibitors

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Biology department

The Department of Biology of the University of Crete was established in 1981 and is today an internationally recognized center for contemporary university education and research in the field of Biology.

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