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Member's area Description Course: BIO 501 Course: BIO 502 Course: BIO 503 Course: BIO 504 Course: BIO 505 Course: BIO 506 Course: BIO 507 Course: BIO 508   COURSE: ΒΙΟ 503   CRYSTALLOGRAPHY & STRUCTURAL PROTEOMICS Coordinators: M. Kokkinidis - Κ. Petratos Credit hours: 20 NOVEMBER 2004 CONTENTS INSTRUCTOR DURATION General Principles of the Crystal Structure Analysis of Biological Molecules Extraction & Crystallization of Proteins Principles of X-ray diffraction & the Phasing Problem Sources of X-rays and Data Collection Strategies Methods of phase determination in macromolecular crystallography: MIR, MAD, MR N. Glykos Μ. Kokkinidis Μ. Kokkinidis Κ. Petratos Κ. Petratos 6 hours 3 hours 4 hours 3 hours 4 hours   TOTAL 20 Credit Hours LITERATURE A. Ducruix, R. Giege. (1992) Crystallization of Nucleic Acids and Proteins, a Practical Approach. IRL Press, Oxford. J.P. Glusker, K.N. Trueblood. (1985) Crystal Structure Analysis: A Primer, Oxford University Press. G.H. Stout, L.H. Jensen. (1988) X-ray Structure Determination. A practical Guide, Macmillan Publishing Co., New York T.L. Blundell, L.N. Johnson. (1976) Protein Crystallography, Academic Press, London. J. Drenth (1999) Principles of Protein X-ray Crystallography, Springer Verlag, New York. G.A. Petsko & D. Ringe (2003) Protein Stucture and Function, Sinauer Associates, Inc. Sunderland, U.S.A.

Last revision date: 16 June, 2004