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Cell Growth, Proliferation and Cancer

Winter Semester
Course type: 
Special notes: 
Για τη λήψη του παραπάνω μαθήματος συνιστάται η επιτυχής παρακολούθηση των υποχρεωτικών μαθημάτων Κυτταρική Βιολογία, Μοριακή Βιολογία, Γενετική Ι και Γενετική ΙΙ.
Course units: 
ECTS units: 

Hours per week



Associate Professor


Objectives of the course (preferably expressed in terms of learning outcomes and competences):  To understand the cell biology of carcinogenesis and learn about recent advances in cancer therapy.

Course contents: Introduction in tumourigenesis: proto-oncogenes, oncogenes and oncosupressors; mutagenesis, immortalisation and carcinogenesis; cell cycle control in vertebrate cells; The mitotic spindle checkpoint; Membrane receptors and signal transduction pathways: the ERK, JNK p38MAPK and PI3 kinase pathways; Chromatin remodelling in carcinogenesis; DNA damage and responses;  DNA repair pathways: mismatch repair, nucleotide excision repair, base excision repair, homologous recombination and non-homologous end-joining;  Programmed cell death;  Replicative senescence; Recent advances in cancer therapy.

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The Department of Biology of the University of Crete was established in 1981 and is today an internationally recognized center for contemporary university education and research in the field of Biology.

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